| Top Institutional Holders |
|---|
| Holder | Shares | % Out | Value* | Reported |
|---|
| BlackRock Fund Advisors | 3,523,191 | 5.87 | 26,283,004 | 31-Mar-2013 | | Vanguard Group, Inc. (The) | 3,472,511 | 5.78 | 25,904,932 | 31-Mar-2013 | | State Street Corporation | 2,795,634 | 4.66 | 20,855,429 | 31-Mar-2013 | | BlackRock Institutional Trust Company, N.A. | 1,869,783 | 3.11 | 13,948,581 | 31-Mar-2013 | | F&C Asset Management PLC | 1,510,982 | 2.52 | 11,271,925 | 31-Mar-2013 | | Wellington Management Company, LLP | 1,454,567 | 2.42 | 10,851,069 | 31-Mar-2013 | | Goldman Sachs Group, Inc. | 1,374,453 | 2.29 | 10,253,419 | 31-Mar-2013 | | Dimensional Fund Advisors LP | 1,298,091 | 2.16 | 9,683,758 | 31-Mar-2013 | | FMR, LLC | 7,051,063 | 11.75 | 52,600,929 | 31-Mar-2013 | | Invesco Ltd. | 1,158,236 | 1.93 | 8,640,440 | 31-Mar-2013 |
|
| Holder | Shares | % Out | Value* | Reported |
|---|
| Fidelity Select Portfolios - Biotechnology | 4,520,000 | 7.53 | 33,719,200 | 31-Mar-2013 | | SPDR (R) Ser Tr-SPDR (R) S&P (R) Biotech ETF | 1,432,453 | 2.39 | 10,614,476 | 30-Apr-2013 | | Powershares Exhg Traded Fd-Dynamic Pharmaceuticals Port | 1,046,079 | 1.74 | 7,751,445 | 30-Apr-2013 | | Vanguard Small-Cap Index Fund | 1,001,532 | 1.67 | 11,207,143 | 31-Dec-2012 | | iShares Russell 2000 Index Fund | 954,401 | 1.59 | 7,119,831 | 31-Mar-2013 | | Fidelity Select Portfolios - Health Care | 900,000 | 1.50 | 6,714,000 | 31-Mar-2013 | | iShares Core S&P Smallcap ETF | 887,724 | 1.48 | 6,622,421 | 31-Mar-2013 | | Vanguard Total Stock Market Index Fund | 797,592 | 1.33 | 8,925,054 | 31-Dec-2012 | | Vanguard Small-Cap Growth Index Fund | 704,213 | 1.17 | 7,880,143 | 31-Dec-2012 | | iShares NASDAQ Biotechnology Index Fund | 539,998 | 0.90 | 4,028,385 | 31-Mar-2013 |
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View Transactions for Insiders & Institutional Holders Value shown is computed using the security's price on the report date given. Currency in USD. |