| % of Shares Held by All Insider and 5% Owners: | 8% | | % of Shares Held by Institutional & Mutual Fund Owners: | 10% | | % of Float Held by Institutional & Mutual Fund Owners: | 11% | | Number of Institutions Holding Shares: | 17 |
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| Major Direct Holders (Forms 3 & 4) |
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| Holder | Shares | Reported |
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| SATOMI HAJIME | 467,000 | 13-May-2013 | | KISSEI PHARMACEUTICAL CO., LTD. | 800,000 | 13-Oct-2011 | | IZUMI TATSUO | 56,800 | 13-May-2013 | | SHIGETA HIROAKI | 45,000 | 10-May-2012 | | MATSUDA KAZUKO | 13,805 | 01-Sep-2011 |
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| Top Institutional Holders |
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| Holder | Shares | % Out | Value* | Reported |
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| Essex Woodlands Health Ventures | 1,170,370 | 5.95 | 3,136,591 | 31-Mar-2013 | | Dimensional Fund Advisors LP | 263,937 | 1.34 | 707,351 | 31-Mar-2013 | | First New York Securities L.L.C. | 96,000 | 0.49 | 257,280 | 31-Mar-2013 | | BlackRock Institutional Trust Company, N.A. | 74,796 | 0.38 | 200,453 | 31-Mar-2013 | | Vanguard Group, Inc. (The) | 46,942 | 0.24 | 125,804 | 31-Mar-2013 | | Wells Fargo & Company | 45,026 | 0.23 | 120,669 | 31-Mar-2013 | | CALPERS (California-Public Employees Retirement System) | 42,600 | 0.22 | 114,168 | 31-Mar-2013 | | Geode Capital Management, LLC | 37,660 | 0.19 | 100,928 | 31-Mar-2013 | | Jane Street Holding, LLC | 19,365 | 0.10 | 51,898 | 31-Mar-2013 | | Mitsubishi UFJ Asset Management Co., Ltd | 18,088 | 0.09 | 48,475 | 31-Mar-2013 |
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| Holder | Shares | % Out | Value* | Reported |
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| DFA U.S. Micro Cap Series | 75,542 | 0.38 | 126,910 | 31-Jan-2013 | | Vanguard Extended Market Index Fund | 45,442 | 0.23 | 74,524 | 31-Dec-2012 | | Spartan Extended Market Index Fund | 37,660 | 0.19 | 100,928 | 31-Mar-2013 | | DFA U.S. Small Cap Series | 25,896 | 0.13 | 43,505 | 31-Jan-2013 | | DFA U.S. Targeted Value Portfolio | 23,798 | 0.12 | 39,980 | 31-Jan-2013 | | DFA U.S. Small Cap Value Series | 18,700 | 0.10 | 31,416 | 31-Jan-2013 | | DFA Tax Managed U.S. Targeted Value Port | 19,847 | 0.10 | 33,342 | 31-Jan-2013 | | DFA Tax-Managed U.S. Small Cap Portfolio | 10,669 | 0.05 | 17,923 | 31-Jan-2013 | | DFA U.S. Vector Equity Portfolio | 5,909 | 0.03 | 9,927 | 31-Jan-2013 | | Claymore ETF Tr-Wilshire Micro Cap ETF | 5,386 | 0.03 | 14,434 | 31-Mar-2013 |
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View Transactions for Insiders & Institutional Holders Value shown is computed using the security's price on the report date given. Currency in USD. |
0.25%