| Top Institutional Holders |
|---|
| Holder | Shares | % Out | Value* | Reported |
|---|
| Wellington Management Company, LLP | 11,027,945 | 8.12 | 258,164,192 | 31-Mar-2013 | | Sectoral Asset Management, Inc. | 7,805,288 | 5.75 | 182,721,792 | 31-Mar-2013 | | Vanguard Group, Inc. (The) | 6,514,862 | 4.80 | 152,512,919 | 31-Mar-2013 | | JANUS CAPITAL MANAGEMENT, LLC | 5,646,202 | 4.16 | 132,177,588 | 31-Mar-2013 | | BB Biotech Ag | 5,313,870 | 3.91 | 124,397,696 | 31-Mar-2013 | | Orbimed Advisors LLC. | 5,233,600 | 3.86 | 122,518,576 | 31-Mar-2013 | | Lord Abbett & Co | 4,785,161 | 3.53 | 112,020,619 | 31-Mar-2013 | | Price (T.Rowe) Associates Inc | 22,439,868 | 16.53 | 525,317,309 | 31-Mar-2013 | | Capital World Investors | 15,917,600 | 11.73 | 372,631,016 | 31-Mar-2013 | | Baker Brothers Advisors, LLC | 14,810,559 | 10.91 | 346,715,186 | 31-Mar-2013 |
|
| Holder | Shares | % Out | Value* | Reported |
|---|
| American Funds Insurance Ser-Growth Fund | 7,755,000 | 5.71 | 181,544,550 | 31-Mar-2013 | | Price (T.Rowe) New Horizons Fund | 5,657,200 | 4.17 | 132,435,052 | 31-Mar-2013 | | Price (T.Rowe) Health Sciences Fund | 5,290,000 | 3.90 | 123,838,900 | 31-Mar-2013 | | Smallcap World Fund | 4,445,600 | 3.27 | 104,071,496 | 31-Mar-2013 | | Price (T.Rowe) Small Cap Stock Fund | 2,704,800 | 1.99 | 63,319,368 | 31-Mar-2013 | | Lord Abbett Securities Trust-Fundamental Equity Fund | 2,629,900 | 1.94 | 48,337,562 | 31-Jan-2013 | | Price (T.Rowe) Mid Cap Growth Fund | 2,250,000 | 1.66 | 52,672,500 | 31-Mar-2013 | | American Funds Insurance Ser-Asset Allocation Fund | 2,160,000 | 1.59 | 50,565,600 | 31-Mar-2013 | | Vanguard Small-Cap Index Fund | 1,957,776 | 1.44 | 32,518,659 | 31-Dec-2012 | | Artisan Mid-Cap Fund | 1,883,682 | 1.39 | 44,096,995 | 31-Mar-2013 |
|
View Transactions for Insiders & Institutional Holders Value shown is computed using the security's price on the report date given. Currency in USD. |
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