| Top Institutional Holders |
|---|
| Holder | Shares | % Out | Value* | Reported |
|---|
| Baker Brothers Advisors, LLC | 4,371,129 | 8.87 | 81,040,731 | 31-Dec-2012 | | Deerfield Management | 4,013,500 | 8.14 | 69,393,415 | 31-Mar-2013 | | Wellington Management Company, LLP | 3,454,768 | 7.01 | 64,051,398 | 31-Dec-2012 | | Putnam Investment Management, LLC | 3,030,240 | 6.15 | 56,180,649 | 31-Dec-2012 | | Vanguard Group, Inc. (The) | 3,004,563 | 6.09 | 51,948,894 | 31-Mar-2013 | | Artal Group S.A. | 2,637,200 | 5.35 | 45,597,188 | 31-Mar-2013 | | Palo Alto Investors, LLC | 2,402,394 | 4.87 | 41,537,392 | 31-Mar-2013 | | BlackRock Fund Advisors | 1,832,335 | 3.72 | 31,681,072 | 31-Mar-2013 | | Citadel Advisors LLC | 1,563,124 | 3.17 | 28,980,318 | 31-Dec-2012 | | State Street Corporation | 1,522,906 | 3.09 | 26,331,044 | 31-Mar-2013 |
|
| Holder | Shares | % Out | Value* | Reported |
|---|
| Columbia Acorn Fund | 2,202,196 | 4.47 | 40,828,713 | 31-Dec-2012 | | Putnam Global Health Care Fd | 1,354,000 | 2.75 | 23,085,700 | 28-Feb-2013 | | Vanguard Small-Cap Index Fund | 817,206 | 1.66 | 15,150,999 | 31-Dec-2012 | | iShares Russell 2000 Index Fund | 774,090 | 1.57 | 13,384,016 | 31-Mar-2013 | | Wells Fargo Advantage Discovery Fd | 693,743 | 1.41 | 11,994,816 | 31-Mar-2013 | | Powershares Exhg Traded Fd-Dynamic Pharmaceuticals Port | 684,295 | 1.39 | 11,831,460 | 31-Mar-2013 | | Vanguard Total Stock Market Index Fund | 653,930 | 1.33 | 12,123,862 | 31-Dec-2012 | | SPDR (R) Ser Tr-SPDR (R) S&P (R) Pharmaceuticals ETF | 646,580 | 1.31 | 11,179,368 | 31-Mar-2013 | | Fidelity Select Portfolios - Biotechnology | 628,851 | 1.28 | 10,872,833 | 31-Mar-2013 | | Putnam Voyager Fund | 627,500 | 1.27 | 11,546,000 | 31-Jan-2013 |
|
View Transactions for Insiders & Institutional Holders Value shown is computed using the security's price on the report date given. Currency in USD. |
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