| INSIDER & RULE 144 TRANSACTIONS REPORTED - LAST TWO YEARS |
| Date | Insider | Shares | Transaction | Value* | | 20-Aug-08 | BVF PARTNERS L P/IL
Beneficial Owner (10% or more) | 5,507,674 | Disposition (Non Open Market) at $3 per share. | $16,523,022 | | 20-Aug-08 | BAVP, L.P.
Beneficial Owner (10% or more) | 2,546,747 | Disposition (Non Open Market) at $3 per share. | $7,640,241 | | 20-Aug-08 | BOCK LOUIS C
Director | 2,546,747 | Disposition (Non Open Market) at $3 per share. | $7,640,241 | | 20-Aug-08 | REICH SIEGFRIED
Officer | 24,223 | Disposition (Non Open Market) at $3 per share. | $72,669 | | 20-Aug-08 | MYERS W TODD
Officer | 25,005 | Disposition (Non Open Market) at $3 per share. | $75,015 | | 20-Aug-08 | BURLEY STEPHEN
Officer | 55,731 | Disposition (Non Open Market) at $3 per share. | $167,193 | | 20-Aug-08 | HENNEY CHRISTOPHER S
Director | 97,165 | Disposition (Non Open Market) at $3 per share. | $291,495 | | 20-Aug-08 | GREY MICHAEL G
Officer | 100,000 | Disposition (Non Open Market) at $3 per share. | $300,000 | | 20-Aug-08 | EASTHAM KARIN
Director | 12,500 | Disposition (Non Open Market) at $3 per share. | $37,500 | | 15-Aug-08 | REICH SIEGFRIED
Officer | 1,562 | Option Exercise at $0 per share. | N/A | | 15-Aug-08 | REICH SIEGFRIED
Officer | 781 | Automatic Sale at $2.98 per share. | $2,327 | | 5-Aug-08 | MYERS W TODD
Officer | 1,563 | Option Exercise at $0 per share. | N/A | | 5-Aug-08 | MYERS W TODD
Officer | 781 | Automatic Sale at $2.96 per share. | $2,311 | | 15-Jul-08 | REICH SIEGFRIED
Officer | 1,563 | Option Exercise at $0 per share. | N/A | | 15-Jul-08 | REICH SIEGFRIED
Officer | 781 | Automatic Sale at $3.05 - $3.06 per share. | $2,3852 | | 11-Jul-08 | BVF PARTNERS L P/IL
Beneficial Owner (10% or more) | 12,500 | Purchase at $3.07 per share. | $38,375 | | 10-Jul-08 | BVF PARTNERS L P/IL
Beneficial Owner (10% or more) | 403,200 | Purchase at $3.03 per share. | $1,221,696 | | 9-Jul-08 | BVF PARTNERS L P/IL
Beneficial Owner (10% or more) | 800,300 | Purchase at $3.04 per share. | $2,432,912 | | 8-Jul-08 | BVF PARTNERS L P/IL
Beneficial Owner (10% or more) | 82,100 | Purchase at $2.99 per share. | $245,479 | | 7-Jul-08 | MYERS W TODD
Officer | 1,562 | Option Exercise at $0 per share. | N/A | | 7-Jul-08 | MYERS W TODD
Officer | 781 | Automatic Sale at $1.60 per share. | $1,249 | | 18-Jun-08 | BVF PARTNERS L P/IL
Beneficial Owner (10% or more) | 1,105,257 | Purchase at $1.45 per share. | $1,602,622 | | 16-Jun-08 | REICH SIEGFRIED
Officer | 1,562 | Option Exercise at $0 per share. | N/A | | 16-Jun-08 | REICH SIEGFRIED
Officer | 781 | Automatic Sale at $1.65 per share. | $1,288 | | 5-Jun-08 | MYERS W TODD
Officer | 1,563 | Option Exercise at $0 per share. | N/A | | 5-Jun-08 | MYERS W TODD
Officer | 781 | Automatic Sale at $1.35 per share. | $1,054 | | 15-May-08 | REICH SIEGFRIED
Officer | 1,563 | Option Exercise at $0 per share. | N/A | | 15-May-08 | REICH SIEGFRIED
Officer | 781 | Automatic Sale at $1.45 per share. | $1,132 | | 5-May-08 | MYERS W TODD
Officer | 1,562 | Option Exercise at $0 per share. | N/A | | 5-May-08 | MYERS W TODD
Officer | 781 | Automatic Sale at $1.43 per share. | $1,116 | | 15-Apr-08 | REICH SIEGFRIED
Officer | 1,562 | Option Exercise at $0 per share. | N/A | | 15-Apr-08 | REICH SIEGFRIED
Officer | 781 | Automatic Sale at $1.19 per share. | $929 | | 7-Apr-08 | MYERS W TODD
Officer | 1,563 | Option Exercise at $0 per share. | N/A | | 7-Apr-08 | MYERS W TODD
Officer | 781 | Automatic Sale at $1.30 - $1.37 per share. | $1,0422 | | 4-Apr-08 | BVF PARTNERS L P/IL
Beneficial Owner (10% or more) | 3,104,317 | Statement of Ownership | N/A | | 4-Apr-08 | BVF PARTNERS L P/IL
Beneficial Owner (10% or more) | 1,847,200 | Statement of Ownership | N/A | | 17-Mar-08 | REICH SIEGFRIED
Officer | 1,563 | Option Exercise at $0 per share. | N/A | | 17-Mar-08 | REICH SIEGFRIED
Officer | 781 | Automatic Sale at $4.01 per share. | $3,131 | | 5-Mar-08 | MYERS W TODD
Officer | 1,562 | Option Exercise at $0 per share. | N/A | | 5-Mar-08 | MYERS W TODD
Officer | 781 | Automatic Sale at $4.05 per share. | $3,163 | | 15-Feb-08 | REICH SIEGFRIED
Officer | 1,562 | Option Exercise at $0 per share. | N/A | | 15-Feb-08 | REICH SIEGFRIED
Officer | 781 | Automatic Sale at $4.05 per share. | $3,163 | | 5-Feb-08 | MYERS W TODD
Officer | 1,563 | Option Exercise at $0 per share. | N/A | | 5-Feb-08 | MYERS W TODD
Officer | 781 | Automatic Sale at $4.40 per share. | $3,436 |
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* = Where indicated, some values are estimates.
1 = Potential proceeds estimated by the filer.
2 = Estimated based on the average of multiple prices reported.
3 = Multiple dates reported. Most recent date shown. |
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Insider Trans.