| INSIDER & RULE 144 TRANSACTIONS REPORTED - LAST TWO YEARS |
| Date | Insider | Shares | Transaction | Value* | | 28-May-08 | WILLIAM BLAIR CAPITAL MANAGEMENT VII, LLC
Beneficial Owner (10% or more) | 1,944,961 | Disposition (Non Open Market) at $1.35 per share. | $2,625,697 | | 28-May-08 | MPM BIOVENTURES II QP LP
Beneficial Owner (10% or more) | 3,028,082 | Disposition (Non Open Market) at $1.35 per share. | $4,087,910 | | 28-May-08 | HATTENDORF JOSEPH MARK
Director | 4,000 | Disposition (Non Open Market) at $1.35 per share. | $5,400 | | 28-May-08 | TIBBITTS GREGORY J
Officer | 230,119 | Disposition (Non Open Market) at $1.35 per share. | $310,660 | | 28-May-08 | TIBBITTS GREGORY J
Officer | 34,082 | Purchase at $0.62 per share. | $21,130 | | 28-May-08 | COONEY DAVID J
Director | 502,938 | Disposition (Non Open Market) at $1.35 per share. | $678,966 | | 28-May-08 | GRIFFIN JERRY C
Director | 17,864 | Disposition (Non Open Market) at $1.35 per share. | $24,116 | | 28-May-08 | GRIFFIN JERRY C
Director | 17,864 | Purchase at $0.62 per share. | $11,075 | | 28-May-08 | MINOCHERHOMJEE ARDA
Director | 1,944,961 | Disposition (Non Open Market) at $1.35 per share. | $2,625,697 | | 28-May-08 | BRENNAN EDWARD F
Officer | 606,610 | Disposition (Non Open Market) at $1.35 per share. | $818,923 | | 28-May-08 | BRENNAN EDWARD F
Officer | 177,902 | Purchase at $0.62 per share. | $110,299 | | 28-May-08 | WHEELER KURT
Director | 3,028,082 | Disposition (Non Open Market) at $1.35 per share. | $4,087,910 | | 23-May-08 | BRENNAN EDWARD F
Officer | 51,200 | Disposition (Non Open Market) at $0 per share. | N/A | | 8-Apr-08 | TIBBITTS GREGORY J
Officer | 100,000 | Acquisition (Non Open Market) | N/A | | 8-Apr-08 | BRENNAN EDWARD F
Officer | 300,000 | Acquisition (Non Open Market) | N/A |
|
* = Where indicated, some values are estimates.
1 = Potential proceeds estimated by the filer.
2 = Estimated based on the average of multiple prices reported.
3 = Multiple dates reported. Most recent date shown. |
|
Insider Trans.