| Insider Transactions Reported - Last Two Years |
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| Date | Insider | Shares | Type | Transaction | Value* |
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| 14-Dec-2012 | RENAUD RONALD C JROfficer | 74,990 | Direct | Option Exercise at $2.41 - $2.96 per share. | N/A | | 16-Mar-2012 | FANNING PAULOfficer | 30,000 | Direct | Sale at $11.04 per share. | 331,200 | | 16-Mar-2012 | FANNING PAULOfficer | 30,000 | Direct | Option Exercise at $2.41 per share. | 72,300 | | 23-Feb-2012 | NOVARTIS AGOther | 84,893 | Indirect | Purchase at $2.41 - $7.39 per share. | N/A | | 22-Nov-2011 | NOVARTIS AGOther | 50,530 | Indirect | Purchase at $2.41 - $5.46 per share. | N/A | | 27-Oct-2011 | BROOKSIDE CAPITAL MANAGEMENT LLCBeneficial Owner (10% or more) | 10,987,500 | Indirect | Statement of Ownership | N/A |
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| Data provided by EDGAR Online |
* = Where indicated, some values are estimates. 1= Potential proceeds estimated by the filer. 2= Estimated based on the average of multiple prices reported. 3= Multiple dates reported. Most recent date shown.
Currency in USD.
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