| Individual/Entity | Most Recent Trans. | Shares Owned as of Trans. Date |
|---|
ABINGWORTH LLP Beneficial Owner (10% or more) | Sale 19-Apr-2012 | 1,599,168
19-Apr-2012 | ANDERSON JOSEPH Director | Acquisition (Non Open Market) 11-Oct-2011 | 11,683 11-Oct-2011 | GORDON CARL L Director | Automatic Sale 04-Sep-2012 | 5,700
04-Sep-2012 | HEALY JAMES Director | Option Exercise 31-Aug-2012 | 6,411,588 31-Aug-2012 | HUFF PAUL Officer | Sale 27-Jul-2012 | 0 27-Jul-2012 | KENNEDY JOSEPH T Officer | Automatic Sale 27-Jul-2012 | 0 27-Jul-2012 | ORBIMED ADVISORS LLC Director | Automatic Sale 04-Sep-2012 | 5,700
04-Sep-2012 | SEDLACK STUART D Officer | Automatic Sale 27-Jul-2012 | 0 27-Jul-2012 | THERO JOHN F Officer | Option Exercise 29-May-2013 | 50,450 29-May-2013 | VAN HEEK G JAN Director | Acquisition (Non Open Market) 10-Apr-2013 | 23,448 10-Apr-2013 | ZAKRZEWSKI JOSEPH S Officer | Option Exercise 25-Apr-2013 | 121,937 25-Apr-2013 |
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